Taking a data-driven approach to drug discovery

  

We collaborate with the world’s leading pharma and biotech companies to lower the risks and time frames in drug discovery through ready-to-use, AI-driven applications and capabilities. Euretos ApproachjWe have developed a unique, data-driven approach for discovering, as well as, evaluating potential novel gene-disease combinations.

Our approach: 

  • Uses AI-powered computational disease models to discover novel targets and indications with low literature bias. 
  • Provides an AI-integrated knowledge base to evaluate predictions against biomolecular data bases, literature and patents.
  • Empowers our client’s domain experts to undertake this evaluation through access to the Euretos AI Platform.

Predictive computational disease models

  

Euretos’ AI-powered computational disease models have been tried and tested in multiple projects with many pharma and biotech companies. These models systematically evaluate gene-disease associations across the whole indication landscape by:

Computational disease models - horizontal

  • Incorporating all indications for which genetic associations with the target of interest have been reported - for complex and monogenic diseases.
  • Constructing the biological network of the target, based on co-expression, protein-protein interactions and pathway annotations.
  • Leveraging these gene network to predict novel associations with indications for which there is no direct genetic association with the target of interest.

Per target, machine learning models calculate for each biological network the indication association scores across the entire disease landscape. These scores are integrated in a single target-indication score and a p-value is estimated based on a comparison to randomly permuted gene networks.

In the indication ranking results, the separate scores for the biological networks of the target are provided to help assess the contribution of each type of molecular interaction to the gene-disease association. This approach provides data-driven insights on novel indications while minimising literature bias. 

Empowering domain experts to draw their own conclusions

 

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The ability to assess the predicted target-indication associations by domain experts is crucial to move a candidate forward in the selection process.

We enable this expert evaluation in two important ways.

First of all we break down the single gene-disease score per type of gene network. For each gene, its interactions in various types of biological molecular networks are evaluated such as  co-expression correlation, protein – protein interactions, pathways associations. For each of these networks we provide the individual scores so domain experts get a sense of which type of molecular interactions provide the strongest contribution to the gene-disease association.

Secondly, we provide domain experts access to the Euretos AI Platform which provides an AI-integrated knowledge base that harmonises supporting evidence from biomolecular databases, publications and patents.

The Euretos platform gives access to key data such as biological interaction networks, gene expression in tissues, cell types and tumors, pathway interactions, regulatory and signaling responses, clinical variant associations with disease and phenotypes, clinical trial outcomes, target tractability and patents.

This approach empowers researchers to further assess the outcomes of the predictive computation disease models and draw their own, evidence-based conclusions.

Enabling world leading pharma, biotech and academic institutions
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