Which genes associated with early onset Alzheimer’s disease have been involved in a clinical trial or study?

In this series we highlight commonly occurring research questions that are normally difficult to answer, but easy to do in the Euretos platform. It demonstrates how researchers are empowered to undertake much more challenging research questions leading to significantly greater, data driven disease insights.

Which genes associated with early onset Alzheimer’s disease have been involved in a clinical trial or study?

This research question can be quickly answered by searching for early onset Alzheimer’s disease in the Euretos Search engine and then clicking on the ‘genes’ category button. This provides a list of genes of over 300 human genes that are mentioned together with early onset Alzheimer’s disease in publications as well as databases. The Euretos AI Platform automatically includes all synonyms in this search.

 

So how many of these 300+ genes have been mentioned in the context of a clinical trial or study? This question can be answered very easily by using one of the over 20 filters that exist for gene lists which can filter out clinical trials and clinical studies:

 

 

Applying this filter creates a list of 30 genes that are associated with early onset Alzheimer’s disease that also have a clinical reference. Only these clinical references are shown which can be immediately accessed and read: 

APLP1, APOE, APP, ATP5J, B3GNT2, BACE1, C9ORF72, CCM2, CTSD, CTSF, DLX4, DNM1L, GABPA, GNA14, GRN, IL10, IL6, JAM2, MAPT, MFN1, NHS, NOTCH3, PRNP, PSEN1, PSEN2, SORL1, TNF, TPM3, VPS13A, YWHAQ.

This is just one of the ways in which the category buttons together with the filters can be used to create very specific gene sets with just a few clicks.

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